“Hopefully in future, clinicians can accurately tailor the right combination of drugs and thus offer a more targeted treatment approach for all diabetic patients,” added Dr Hou, the recipient of the inaugural Postdoctoral Fellowship offered by the medical school in 2014. Neutrophils as new biomarkers The NTU team discovered that neutrophils can be used as a biomarker to determine if diabetic patients are suffering from an inflammation. Using the new test kit, neutrophils can be easily extracted from a blood sample, and their behaviour and function observed for more efficient inflammation profiling in additional to the cell count. In healthy individuals, neutrophils float free in the blood stream. When there is an acute inflammation such as during a bacterial or viral infection, they will slow down and roll along the vessel walls. Once near the site of infection, they squeeze through the vessel walls and move to the site of the injury. In diabetic patients, the neutrophils roll faster, which means that fewer of them will manage to squeeze through the vessel wall to tackle the infection. 4 year old foot pain at nightThe increased rolling speeds of neutrophils correlate closely with cholesterol and c-reactive protein levels (a biomarker for inflammation) so it provides doctors with a better indicator of an individual’s immune status, Dr Hou explained. The NTU team found that existing drugs prescribed to treat diabetes are able to change the rolling speed of neutrophils, in addition to controlling the blood sugar level. Professor Bernhard Boehm, Scientific Director of the Metabolic Disease Research Programme at the NTU medical school, added that some drugs like Metformin and Pravastatin mitigate cardiovascular risks such as atherosclerosis, the build-up of fatty deposits in arteries which could lead to heart attacks in diabetic patients. http://www.feelfreemaldives.com/wwwfeelfreemaldivescom3132/2016/09/21/is-a-publicly-registered-non-traded-reit-focused-on-acquiring-a-portfolio-consisting-primarily-of-single-tenant-business-essential-properties-throughout-the-united-states-diversified-by-corporate-cre/“In doing so, these drugs may improve neutrophil function, as neutrophils are a key driver in atherosclerosis.
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